Synonyms: AC-137 peptide; Amylin peptide; Amylin (human) (DAP) (human); Diabetes Associated Peptide
CAS No.: Not available.
Molecular Weight: 3949.45
Chemical Formula: C171H267N51O53S2
Product Codes: 3845
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Pramlintide N/A 100% Yes
Emergency Overview
--------------------------
WARNING! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. MAY CAUSE ALLERGIC REACTION.
Potential Health Effects
----------------------------------
This material is a hormone secreted from the pancreatic islets along with insulin in response to stimulation by nutrient secretagogue. In islolated skeletal muscle, the protein inhibits insulin-stimulated incorporation of glucose into glycogen, causes glycogenolysis, and increases lactate production. The full chemical, physical and toxicological properties of this protein have not been thoroughly investigated. Therefore, exercise due care when handling this material.
Inhalation:
No information found, but inhalation of dust may produce irritation, and an allergic reaction.
Ingestion:
No information found, but ingestion may produce an allergic reaction.
Skin Contact:
No information found, but skin contact may produce irritation, and an allergic reaction.
Eye Contact:
No information found, but may cause irritation.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
If swallowed, give large quantities of water to drink and get medical attention immediately. Never give anything by mouth to an unconscious person.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.
Store at or below -20C (Deep Freeze) in a desiccated environment and protected from light. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
None established.
Ventilation System:
In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort to the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Safety glasses. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:
White fluffy powder.
Odor:
Odorless.
Solubility:
25 mg/mL in water.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
No information found.
Melting Point:
No information found.
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
No information found.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
No incompatibility data found.
Conditions to Avoid:
No information found.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Pramlintide No No None
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Not regulated.
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Pramlintide Exempt No No No
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Pramlintide No No No No
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Pramlintide No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Pramlintide No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 1 Flammability: 0 Reactivity: 0
Label Hazard Warning:
WARNING! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. MAY CAUSE ALLERGIC REACTION.
Label Precautions:
Avoid breathing dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use with adequate ventilation.
Keep away from heat, sparks and flame.
Wash thoroughly after handling.
INTENDED FOR FDA REGULATED USE ONLY.
NOT ON THE TSCA INVENTORY.
Label First Aid:
If inhaled, remove to fresh air. Get medical attention for any breathing difficulty. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. If swallowed, give large quantities of water to drink and get medical attention immediately. Never give anything by mouth to an unconscious person.
Product Use:
For FDA Regulated Use.
Revision Information:
MSDS Section(s) changed since last revision of document include: 3, 5.
Disclaimer:
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Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)