Synonyms: Acetanilide, 4'-hydroxy-; acetamide, N-(4-hydroxyphenyl)-; APAP; Paracetamol
CAS No.: 103-90-2
Molecular Weight: 151.16
Chemical Formula: C8H9NO2
Product Codes: 0044, 0046, 0048, 0057, 0077, 0084, 0167, 0169, 0422, 0894, 0895, 0896, 0935, 1125, 1617, 1680, 3065, 3477, 4814, 4864, 5541, 5542, 5543, 6088, 6135, 6375, 7250, 7325, 7375, 7580, 7845
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Acetaminophen 103-90-2 100% Yes
Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED OR INHALED. OVERDOSAGE MAY AFFECT LIVER AND KIDNEYS. MAY CAUSE SKIN RASH OR ALLERGIC REACTION. MAY FORM COMBUSTIBLE DUST CONCENTRATIONS IN AIR.
Potential Health Effects
----------------------------------
Inhalation:
May produce an allergic response in sensitized individuals. Symptoms may include rash or wheezing.
Ingestion:
Severe overdosage may produce nausea, vomiting, perspiration, and general discomfort. Massive overdosage may produce damage to liver, kidneys, and central nervous system. Potentially toxic single dose: 10-15 grams; 25 grams is potentially fatal.
Skin Contact:
May produce allergic responses paralleling inhalation.
Eye Contact:
May cause mechanical irritation.
Chronic Exposure:
Repeated ingestion of toxic doses may produce cirrhosis of the liver.
Aggravation of Pre-existing Conditions:
Individuals exposed to alcohol or other drugs may be more susceptible to the toxic effects of this substance.
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Wash exposed area with soap and water. Get medical advice if irritation develops.
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Maximum Explosion Pressure Pm (bar): 8.7 Maximum Rate of Pressure Rise dP/dt (bar/s): 843 Kst (bar.m/s): 229 Minimum Ignition Energy (mJ): 5-10 Minimum Ignition Temperature C (Dust Cloud): 590 Minimum Ignition Temperature C (Dust Layer): > 400 Limiting Oxygen Concentration (%): 10-11 Minimum Explosible Concentration (g/m3): 50-60 Volume Resistivity-Ambient R.H. (ohm.m): > 1014 Volume Resistivity-Low R.H. (ohm.m): > 1014 Charge Decay Time-Ambient (hours): 1.4 Charge Decay Time-Low (hours): 5.5
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.
Keep in a well closed container stored under cold to warm conditions, 2 to 40 C, (36 to 104F). Acetaminophen is capable of generating a static electrical charge. If process involves dumping Acetaminophen into flammable liquid, provide inert atmosphere in vessels or maintain flammable liquid below its flashpoint. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
Mallinckrodt recommends an exposure limit of 5 mg/m3
Time Weighted Average (TWA) for acetaminophen.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face dust/mist respirator may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece dust/mist respirator may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Gloves and lab coat, apron or coveralls.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:
White powder or granules.
Odor:
Odorless.
Solubility:
ca. 1.1 g/100g water @ 25C (77F).
Specific Gravity:
ca. 1.29
pH:
5.1 - 6.5 (saturated solution)
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
Not applicable.
Melting Point:
ca. 170C (ca. 338F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
In the presence of heat and water, substance will hydrolyze into acetic acid and p-aminophenol. Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
No information found.
Conditions to Avoid:
No information found.
Oral rat LD50: 2404 mg/kg; investigated as a mutagen, tumorigen, reproductive effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Acetaminophen (103-90-2) No No 3
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Not regulated.
R18.....(In use, may form flammable/explosive vapour-air mixture)
R22.....(Harmful if Swallowed)
R36/37/38.....(Irritating to eyes, respiratory system and skin)
S26.....( In case of contact with eyes, rinse immediately with plenty of water and seek medical advice)
S36.....(Wear suitable protective clothing)
S33.....(Take precautionary measures against static discharges)
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Acetaminophen (103-90-2) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Acetaminophen (103-90-2) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Acetaminophen (103-90-2) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Acetaminophen (103-90-2) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: Yes Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: S2
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED OR INHALED. OVERDOSAGE MAY AFFECT LIVER AND KIDNEYS. MAY CAUSE SKIN RASH OR ALLERGIC REACTION. MAY FORM COMBUSTIBLE DUST CONCENTRATIONS IN AIR.
Label Precautions:
Avoid breathing dust.
Wash thoroughly after handling.
Keep container closed.
Avoid dust cloud in presence of an ignition source.
Use with adequate ventilation.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. Get medical attention for any breathing difficulty. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes.
Product Use:
Medication: Analgesic agent
Revision Information:
MSDS Section(s) changed since last revision of document include: 5.
Disclaimer:
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Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)