Synonyms: 4-Aminophenol; Rodinol; Ursal P; para-Hydroxyaniline; PAP low sulfite
CAS No.: 123-30-8
Molecular Weight: 109.1
Chemical Formula: C6H7NO
Product Codes: 0121, 0187, 8509
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- 4-Aminophenol 123-30-8 100% Yes
Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE METHEMOGLOBINEMIA. Very toxic to aquatic organisms; may cause long term adverse effects in the aquatic environment.
Potential Health Effects
----------------------------------
Inhalation:
Not highly toxic. Exposure to high concentrations may result in transient central nervous system depression and formation of methemoglobin with accompanying symptoms of blue lips (cyanosis).
Ingestion:
Toxic. Ingestion of large amounts may cause effects similar to inhalation. Animal studies indicate kidney damage from acute oral exposure.
Skin Contact:
May cause skin discoloration, sensitization, and dermatitis. Not highly toxic; however, systemic effects from skin absorption of aqueous solutions have been reported that include restlessness and convulsions.
Eye Contact:
May cause irritation.
Chronic Exposure:
Lengthy exposures may affect the ability of blood to carry oxygen (methemoglobinemia), resulting in bluish discoloration of lips and tongue (cyanosis).
Aggravation of Pre-existing Conditions:
Hypersensitive persons or persons with pre-existing kidney, respiratory, skin, or blood disorders may be more susceptible to the effects of this substance.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.
Airborne Exposure Limits:
Para Aminophenol: Mallinckrodt recommends an exposure limit of 2 mg/m3 Time Weighted Average (TWA)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, a half facepiece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest.. A full-face piece particulate respirator (NIOSH type N100 filters) may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:
Light tan to crystalline powder. Discolors to lavender when exposed to air.
Odor:
Faint amine odor.
Solubility:
Slight in water; complete in hot dilute acids.
Specific Gravity:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
284C (543F)
Melting Point:
180 - 190C (356 - 374F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Has strong reducing properties. Slowly decomposes on exposure to air and sunlight. Reacts with both acids and bases.
Hazardous Decomposition Products:
Burning may produce ammonia, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Reacts with oxidizing agents; contact with peroxides and nitrates should be avoided. Contact with concentrated nitric acid is expected to be highly exothermic.
Conditions to Avoid:
No information found.
Oral rat LD50: 375 mg/kg; investigated as a mutagen, reproductive effector. Unpublished information: Dermal LD50 - Rabbit: > 8.00 gm/Kg Eye Irritation - Rabbit: Not an eye irritant Inhalation - Rats: No deaths at concentration of 5.91 mg/l of air for 60 minutes.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
4-Aminophenol (123-30-8) No No None
Environmental Fate:
No information found.
Environmental Toxicity:
Dangerous to the environment. Very toxic to aquatic organisms; may cause long term adverse effects in the aquatic environment.
Approximate fatal concentration for goldfish was 2.0mg/mL in a 48 hour test.
Toxicity to Algae, Species: Chlorella pyrenoidosa -the growth of colonies was inhibited less than 10% at doses of 25 mg/L.
Oncorhyncus Mykiss 96h LC50 1.2 mg/l (ref NORDBAS1)
Pimephales promelas 96h LC50 24 mg/l
LC50 0.1-1.0 mg/l (ref Hommel, handbuch der gefahrlichen Guter Im Goldorfentest)
Daphnia Magna 48h EC50 0.31 mg/l (ref Research Journal WPCF, vol 63f, No4, June 1991)
Daphnia 48h EC50 0.31 mg/l, 0.24 mg/l
Daphnia EC50 0.6 mg/l
Scenedesmus 6 mg/l
microorganism 2 mg/l
Log Kow 0.04 (ref Verschueren K, Handbook of Environmental Data on Organic Chemicals, 1983)
Inherently biodegradable, 87% biodegradation by COD with adapted sludge
(ref Verschueren K, Handbook of Environmental Data on Organic Chemicals, 1983)
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: AMINOPHENOLS
Hazard Class: 6.1
UN/NA: UN2512
Packing Group: III
Information reported for product/size: 500G
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: AMINOPHENOLS
Hazard Class: 6.1
UN/NA: UN2512
Packing Group: III
Information reported for product/size: 500G
R & S Phrases: R:20/21/22, R:68, R:50/53, S:28-36/37-60-61 Symbol Xn, N
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
4-Aminophenol (123-30-8) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
4-Aminophenol (123-30-8) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
4-Aminophenol (123-30-8) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
4-Aminophenol (123-30-8) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: 2X
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 1
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE METHEMOGLOBINEMIA. Very toxic to aquatic organisms; may cause long term adverse effects in the aquatic environment.
Label Precautions:
Avoid breathing dust.
Keep container closed.
Use with adequate ventilation.
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, wipe off excess material from skin then immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. In all cases, get medical attention.
Product Use:
Laboratory Reagent or Process Chemical.
Revision Information:
No Information Found.
Disclaimer:
************************************************************************************************
Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)