MSDS Number: APTAE * * * * * Effective Date: 11/19/99 Amphetamine Aspartate


Amphetamine Aspartate


1. Product Identification

Synonyms: Benzeneethanamine, alpha-methyl-, aspartate
CAS No.: Not available.
Molecular Weight: Not available.
Chemical Formula: Not available.
Product Codes: 3993

2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent   Hazardous                                       
  ---------------------------------------   ------------   -------   ---------        
 
  Amphetamine Aspartate                     N/A              100%       Yes                                                               
 

3. Hazards Identification

Emergency Overview
--------------------------
POISON! DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF INHALED. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. ALLERGEN. EXPOSURE MAY PRODUCE ALLERGIC RESPONSE.

Potential Health Effects
----------------------------------

Inhalation:
Inhalation of dust may cause irritation to respiratory tract. Other symptoms may parallel those from ingestion.
Ingestion:
Adverse effects include bitter taste, a false sense of well-being, nervousness, and sleeplessness, (sometimes followed by fatigue, trembling, or mental depression), change in heart rate, blurred vision, constipation, diarrhea, loss of appetite, nausea or vomiting, stomach pain, dizziness, headache, dry mouth, increased sweating, chest pain, breathing difficulty, and mood changes. Allergic reaction may occur.
Skin Contact:
May cause irritation, allergic skin reaction.
Eye Contact:
May cause irritation, redness and pain.
Chronic Exposure:
May cause habituation or addiction. Overdosage can lead to panic, hallucinations, convulsions, coma, and death.
Aggravation of Pre-existing Conditions:
Some individuals may become sensitized from exposure and develop skin rashes, coughs, stuffy nose, asthma, and other allergic complaints. Sensitivity may develop soon after immediate contact or after years of exposure. Persons with impaired kidney function, epilepsy, glaucoma, advanced arteriosclerosis, symptomatic cardivascular disease, hypertension,or hyperthyroidism may be more susceptible to the effects of the substance.

4. First Aid Measures

Persons developing hypersensitivity (anaphylactic) reactions must receive immediate medical attention.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physician, immediately. Wash clothing before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. All clean-up operations should be witnessed by more than one individual. Spills: Carefully sweep up material into an appropriate container and save for reclamation or disposal. Use non-sparking tools and equipment. Do not flush to sewer! The amount of material collected should be assessed and documented.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect from physical damage and direct sunlight. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. CONTROLLED SUBSTANCE. Location of storage area must comply with all Drug Enforcement Agency regulations.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures:
Allergic responses in sensitive individuals will disappear if removed from exposure.

9. Physical and Chemical Properties

Appearance:
White powder.
Odor:
Odorless.
Solubility:
Soluble in water.
Density:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
No information found.
Melting Point:
No information found.
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Toxic gases and vapors may be released if involved in a fire.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong alkalis and calcium salts.
Conditions to Avoid:
No information found.

11. Toxicological Information

Reproductive Toxicity:
The theraputic use of amphetamines during pregnancy may be associated with an increased risk of congenital malformations in the fetus. Reproductive studies in animals have suggested both an embryotoxic and a teratogenic potential when amphetamines were administered in high multiples of the human dose.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Amphetamine Aspartate                   No          No            None

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Notify site Drug Enforcement Agency compliance officer and local DEA office for appropriate disposal procedures. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Amphetamine Aspartate                           Exempt No    No       No                                        
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Amphetamine Aspartate                             No    No    No     No                              
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Amphetamine Aspartate                      No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Amphetamine Aspartate                      No         No         No                   
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: No  Pressure: No
Reactivity: No          (Pure / Solid) 


Australian Hazchem Code: None allocated.
Poison Schedule: S7
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 3 Flammability: 1 Reactivity: 0
Label Hazard Warning:
POISON! DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF INHALED. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. ALLERGEN. EXPOSURE MAY PRODUCE ALLERGIC RESPONSE.
Label Precautions:
Avoid breathing dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
Handle with exceptional care.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. In all cases call a physician.
Product Use:
Medication.
Revision Information:
New MSDS.
Disclaimer:
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Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)