Synonyms: Morphine chloride; Morphine Hydrochloride ARS-(FOR R&D USE ONLY)
CAS No.: 52-26-6 (Anhydrous)
Molecular Weight: 375.81
Chemical Formula: C17H19NO3.HCl.3H2O
Product Codes: 1429, 1644
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------- --------- Morphine hydrochloride 52-26-6 100% Yes
Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. ALLERGEN. EXPOSURE MAY PRODUCE ALLERGIC RESPONSE. NARCOTIC.
Potential Health Effects
----------------------------------
Inhalation:
Narcotic. Can irritate the respiratory passages and cause sneezing or coughing but will also have an anesthetic effect. Inhalation of appreciable quantities may produce lung edema, dizziness, and respiratory difficulties, see also Ingestion, below.
Ingestion:
Toxic! Narcotic. Human lethal dose probably 120-250 mg. In addition to its analgesic action, morphine may cause gastric disturbance with nausea, vomiting and constipation. Large amounts may cause central nervous system depression, respiratory or cardiac collapse, coma and death.
Skin Contact:
Not expected to cause health effects, although the possibility of absorption exists under conditions of skin breakage or inflammation.
Eye Contact:
Mild irritant but will also have a strong narcotic effect (pupil contraction) and the eye may serve as an absorption route to the body in general.
Chronic Exposure:
May cause habituation or addiction.
Aggravation of Pre-existing Conditions:
Some individuals may become sensitized from exposure and develop skin rashes, coughs, stuffy nose, asthma, and other allergic complaints. Sensitivity may develop soon after immediate contact or after years of exposure.
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Call a physician, immediately. Wash clothing before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. All clean-up operations should be witnessed by more than one individual. Spills: Carefully sweep up material into an appropriate container and save for reclamation or disposal. Use non-sparking tools and equipment. Do not flush to sewer! The amount of material collected should be assessed and documented.
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect from physical damage and direct sunlight. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. CONTROLLED SUBSTANCE. Location of storage area must comply with all Drug Enforcement Agency regulations.
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles.
Other Control Measures:
Allergic responses in sensitive individuals will disappear if removed from exposure.
Appearance:
Fine white to slightly yellow-white powder.
Odor:
Odorless.
Solubility:
Slightly soluble in water.
Density:
No information found.
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
No information found.
Melting Point:
ca. 200C (ca. 392F) Decomposes.
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
Stability:
Discolors on exposure to light.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Alkalis, tannin, strong oxidizing agents, borax, ferric chloride, iodides, lead acetate, mercuric chloride, gold salts.
Conditions to Avoid:
No information found.
Oral rat LD50: 335 mg/kg; oral mouse LD50: 745 mg/kg; investigated as a mutagen, reproductive effector.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Morphine hydrochloride (52-26-6) No No None
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
Notify site Drug Enforcement Agency compliance officer and local DEA office for appropriate disposal procedures. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
Not regulated.
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Morphine hydrochloride (52-26-6) Exempt Yes No Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Morphine hydrochloride (52-26-6) Yes No No No
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Morphine hydrochloride (52-26-6) No No No No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Morphine hydrochloride (52-26-6) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: S8
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.
NFPA Ratings: Health: 3 Flammability: 1 Reactivity: 0
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED. HARMFUL IF INHALED OR ABSORBED THROUGH SKIN. ALLERGEN. EXPOSURE MAY PRODUCE ALLERGIC RESPONSE. NARCOTIC.
Label Precautions:
Avoid breathing dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Wash thoroughly after handling.
Use with adequate ventilation.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. In all cases, get medical attention.
Product Use:
Medication: Analgesic; for relief of moderate to moderately severe pain.
Revision Information:
No changes.
Disclaimer:
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Mallinckrodt provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)